Proinflammatory gene expression from peripheral blood cells in patients with fructose/lactose intolerance and healthy controls.

Background Nutrition with antioxidant capacity can have important effects on the proinflammatory status of individuals. Fruit and vegetable consumption was been reported to influence proinflammatory gene expression. Patients with fructose/lactose intolerance represent a group of controlled dieters. The current study assessed the potential difference of proinflammtory gene expression between fructose/lactose intolerant patients and healthy controls. Methods In total 71 subjects were investigated.

Reduced dopamine D3 receptor expression in blood lymphocytes of smokers is negatively correlated with daily number of smoked cigarettes: a peripheral correlate of dopaminergic alterations in smokers

The mesolimbic dopaminergic system is known to mediate rewarding effects of nicotine administration, and dysfunctions of this system may underlie failure to stop cigarette smoking. Expression of dopamine receptors in peripheral blood lymphocytes (PBLs) has been indicated as a peripheral correlate of brain status. Dopamine receptor D(3) (DRD3) and D(4) (DRD4) mRNA expression in PBLs was measured by real-time polymerase chain reaction in smokers (n=26) and former smokers (n=14), compared with nonsmoking control subjects (n=35).